The Katritch Lab Developed a New Molecular Design Concept to Discover New Bitopic Ligands

The Katritch lab developed a new molecular design concept to discover new bitopic ligands that target sodium pockets, specifically in Opioid GPCRs. This study demonstrated the unique functional profile of mu-opioid bitopics, including side effect-free analgesia in-vivo, and has been published in Nature (link to article) and highlighted in USC News (link to publication).