Dr. Maxime Tortora Co-Led a Study Published in Molecular Cell

QCB postdoc Dr. Maxime Tortora (left) from Dr. Geoff Fudenberg's (right) lab co-led the study published in Molecular Cell, titled "Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption". This joint work with the group of Dr. Elphege Nora at UCSF uncovers how the kinetic properties of cohesins, the molecular motors organizing our genomes in interphase, are regulated. By comparing simulations with data, the authors found that the rate of loop extrusion is modulated by cofactor dosage, thus characterizing a new 'dial' for cells to tune motor properties and the overall folding of the genome. Please read the paper here.